[SEMINAR:001483] Tokyo:Univ.Tokyo, Inst.Med.Sci.

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<pre> GCOE seminar Date: August 4, 1130-1230 at Seminar room, 1st building 2nd floor, Institute of Medical Science, University of Tokyo (Subway Namboku / Mita line, Shirokene-dai station) Admission free. Colony stimulating factors, macrophages and inflammatory/autoimmune disease John A Hamilton, Director Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Victoria, Australia Although originally defined as hematopoietic-cell growth factors, colony-stimulating factors (CSFs) have been shown to have additional functions by acting directly on mature myeloid cells. Recent data from animal models indicate that their depletion has therapeutic benefit in many inflammatory and/or autoimmune conditions and as a result early phase clinical trials targeting granulocyte/macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF or CSF-1) have now commenced. The distinct biological features of CSFs offer specific targeting opportunities but with some associated risks. Here, I describe these biological features, discuss the likely specific outcomes of targeting CSFs in vivo and highlight outstanding questions that need to be addressed. *** Sumiko Watanabe Inst. Med. Sci., Univ. Tokyo </pre>

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