[SEMINAR:001486] IMSUT, Tokyo

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<pre> GCOE Program Seminar 入場無料、事前のご連絡不要です。皆様のご来聴をお 待ちしております。 Date and Time： August 4 , 2010 11：30 - 12：30 Venue : Inst. Med. Sci, Univ. Tokyo, 1st Building, 2F Conference Room （東京大学医科学研究所、1号館、２階会議室） Speaker： Dr. John A. Hamilton PhD, DSc., Professorial Fellow &amp; Director Affiliation：Arthritis and Inflammation Research Centre ,The University of Melbourne Department of Medicine, Royal Melbourne Hospital, Victoria, Australia Seminar Title : Colony stimulating factors, macrophages and inflammatory/autoimmune disease Summary： Although originally defined as hematopoietic-cell growth factors, colony-stimulating factors (CSFs) have been shown to have additional functions by acting directly on mature myeloid cells. Recent data from animal models indicate that their depletion has therapeutic benefit in many inflammatory and/or autoimmune conditions and as a result early phase clinical trials targeting granulocyte/macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF or CSF-1) have now commenced. The distinct biological features of CSFs offer specific targeting opportunities but with some associated risks. Here, I describe these biological features, discuss the likely specific outcomes of targeting CSFs in vivo and highlight outstanding questions that need to be addressed. Host： Sumiko Watanabe (Division of Molecular and Developmental Biology), Kiyono Hiroshi (Division of Mucosal Immunology) </pre>

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